Iodine-induced thyroiditis was inhibited, at least in part, by the increased number of regulatory T-cells in NOD.H-2h4 mice expressing transgenic transforming growth factor (TGF)-β on thyrocytes [83]; while depletion of regulatory T-cells by anti-CD25 antibody before iodine treatment significantly exacerbated iodine-induced thyroiditis and increased anti-thyroglobulin antibody titers [84]. This evidence concerns the gene TG and thyroid gland disorder.