MIF and cancer: In vitro MIF reduction by ISO-1, has been reported to effectively reduce cancer cell proliferation, migration, and invasion of the human lung adenocarcinoma A549 (10,13) decrease the proliferation and invasiveness of prostate cancer DU-145 cells (9), restore contact inhibition of proliferation of LN 229 and LN -18 glioblastoma cells (14), reduce cell migration and invasion of HS683 glioma cells (15), and suppress the proliferation of the murine colorectal cancer cells CT-26 (16).