BCAT2 and obesity due to melanocortin 4 receptor deficiency: An example of earlier evidence pointing to a role of adipose tissue in obesity-associated BCAA dysregulation comes from observations of reduced expression of mitochondrial branched-chain amino acid aminotransferase (Bcat2) and branched-chain α-keto acid dehydrogenase (Bckdha) enzymes in epididymal fat from ob/ob mice and Zucker rats, compared to their lean counterparts [16].