After determining protein levels in the CSF, data analysis was performed using a multivariate discriminant algorithm, which identified specific CSF concentrations of MMP-2, 9 and TIMP-1 as the proteins that contributed the most to the separation between SVD and AD, with high sensitivity (89%), specificity (90%), and area under the ROC curve (0.92) [19]. The gene discussed is TIMP1; the disease is Alzheimer disease.