IFNG and Chagas disease: Some studies on other intracellular pathogens demonstrated that the simultaneous raise of IFN-γ and IL-10 has a beneficial role in parasite control and in the prevention of tissue damage [7, 44, 45]. In vitro studies, particularly on Chagas disease, have demonstrated that high IL-10 levels are capable of inhibiting the intracellular destruction of T. cruzi [46, 47].