In samples from 49 breast cancer patients, the single-cell infiltration pattern that is observed in some lobular carcinomas has been linked to protein truncation mutations in the CDH1 gene encoding for E-cadherin [86], and hypoxia-induced upregulation of Slug and Snail is associated with increased breast cancer cell migration and invasion in vitro[77]. This evidence concerns the gene CDH1 and breast lobular carcinoma.