Concerning the precision of thalassemia diagnosis, the red blood cells from Hb E donors (Hb E trait or homozygous Hb E) can cause the misdiagnosis of thalassemia in the normal recipients (false positive) or the red blood cells from normal donors can cause the misdiagnosis of thalassemia in the thalassemic recipients (false negative) [6]. The gene discussed is GSTM1; the disease is thalassemia.