As titration in this study was at the treating physicians’ discretion, the difference in the incidence of hypoglycaemia in favour of the insulin detemir group may be partly because of the varying up-titration between the two groups and the slightly higher HbA1c values at final visit (7.48% vs. 7.38%) in patients treated with insulin detemir. This evidence concerns the gene INS and Hypoglycemia.