REN and diabetes mellitus: The results of a multiple regression analysis that included age, gender, hemoglobin, albumin, eGFR, prevalence of diabetes, use of renin-angiotensin-aldosterone blockers, and the switch from allopurinol to febuxostat showed that treatment with febuxostat independently associated with the change in eGFR (β = 0.22145, P < 0.05, Table. 4).