In general, the expression of CD36 can be regulated at the transcriptional, translational, or post-translational levels, In the promotion of hepatic steatosis, CD36 is a transcriptional target of orphan nuclear receptors including liver X receptor (LXR), pregnane X receptor (PXR) and peroxisome proliferator-activated receptor γ (PPARγ) [18]. This evidence concerns the gene NR1I2 and fatty liver disease.