Conversely, the down-regulation of one enzyme involved in mitochondrial FFA biosynthesis and three proximal Krebs cycle enzymes (aconitase, isocitrate dehydrogenase, α-ketoglutarate dehydrogenase) suggest that the capacity of these acetyl-CoA-consuming pathways is decreased in HE mice. Here, IDH3A is linked to hereditary elliptocytosis.