The 2D-DIGE analysis carried out on the whole hepatocyte proteome revealed that several enzymes involved in the defense against oxidative stress, i.e. peroxiredoxin 1, glutathione-S-transferases (Mu and P classes) and carbonic anhydrase 3, are strongly up-regulated in HE mice. This evidence concerns the gene PRDX1 and hereditary elliptocytosis.