In addition to aconitase, isocitrate dehydrogenase and α-ketoglutarate dehydrogenase down-regulation, we noticed that three other Krebs cycle enzymes, namely succinyl-CoA dehydrogenase, fumarase and malate dehydrogenase, are strongly up-regulated in HE mice. The gene discussed is FH; the disease is hereditary elliptocytosis.