In the current model, we did not take into account many factors such as cell migration [1], angiogenesis, stromal cells within the tumor [80], constant remodeling of ECM from blood flow, immune system control or growth factors [81] such as epidermal growth factors (EGF) [82] and fibroblast growth factors (FGF) [83] that may play significant roles in regulating efficacy of oncolytic virus therapy. Here, EGF is linked to neoplasm.