Consistent with in vitro observations, we also confirmed that the enforced expression of KIF5B-RET caused a significant increase in A549 xenograft tumor weight in nude mice compared with control (KIF5B-RET group vs control group: 0.53 ± 0.2 g vs 0.22 ± 0.15 g, ***P < 0.001; Figure 3). This evidence concerns the gene KIF5B and neoplasm.