On the other hand, in the report in Journal of Clinical Oncology, Wang et al.[29] found that all RET-positive adenocarcinomas had a small primary lesion but tended to present with N2 disease significantly more often than the other lung adenocarcinomas with small lesions (P < 0.024), which showed KIF5B-RET positive tumor may have stronger local invasion ability. This evidence concerns the gene KIF5B and lung adenocarcinoma.