In contrast to 13 fusion partner genes of RET in thyroid carcinoma, only KIF5B-RET, CCDC6-RET, TRIM33-RET and NCOA4-RET have been reported in lung cancer, and KIF5B-RET is the most commonly identified gene fusion in NSCLCs to date[29,32]. The gene discussed is KIF5B; the disease is lung cancer.