Besides the validation of significant susceptibility of ALDH2 rs671 polymorphism to CAD, we additionally identified a synergistic interaction between rs671 and another individually significant polymorphism rs2073478 in ALDH1b1. On one hand, this interaction was reflected in our allele combination analysis, as the combination simultaneously possessing the two ‘risk’ alleles of these two polymorphisms was associated with a greater risk of CAD, which was further observed to be mediated via regulating lipid profiles by our allele combination-phenotype analysis. The gene discussed is ALDH1B1; the disease is coronary artery disorder.