In preclinical studies, treatment with the VEGF receptor (VEGFR) inhibitor sunitinib induced dose-dependent increases in VEGF and PlGF levels and decreases in soluble VEGFR 2 (sVEGFR2) levels, while treatment with cetuximab, an epidermal growth factor receptor antibody, increased transforming growth factor alpha levels in a tumor-independent manner [11,12]. This evidence concerns the gene VEGFA and neoplasm.