PIK3R2 and breast carcinoma: PAX2. Implicated in suppression of translation (through WT1). Associated to low breast cancer risk. Repression of PAX2 would promote a more aggressive breast cancer. THTPA. Metastasis tumour suppressor. PIK3R2. Proliferation pathway. Anti-apoptotic. BBC3. Pro-apoptotic gene and associated to tumour size.