RAP1B, family RAS (oncogene). It has a pseudogene. IGF1R Low expression of miR in colo-rectal cancer is associated to more advanced tumours and less survival. FOS proteins are implicated in cell cycle, differentiation and cellular transformation. Dowregulation induces increase in apoptosis and more cellular differentiation. TOP2A, topoisomerase. Upregulation is associated to tumour proliferation. CXCR4, associated with progression and metastasis in CRC. Regulated by HER2-CD44 via miR139. This evidence concerns the gene CD44 and rectal cancer.