Most studies of POU5F1P1 gene polymorphism concern the loci rs10505477; studies have shown that the rs10505477 C > T polymorphism plays an important role in the oncogenesis and progression of colorectal cancer (CRC) [18,19,20,21,22], but not in ovarian cancer [23]. The gene discussed is POU5F1B; the disease is colorectal cancer.