Our group has evaluated in nonagenarians, centenarians, and middle-aged individuals the angiotensin-converting enzyme (ACE) gene, which is an important gene of the renin-angiotensin-aldosterone system (RAAS) that has been involved in the pathogenesis of hypertension, coronary artery disease, heart failure, and recently longevity [31]. The gene discussed is ACE; the disease is hypertensive disorder.