To explore the potential functional role of the 2 identified lncRNAs with close correlation with the clinical features of the tongue SCC patients, we treated the cancer cell HN21B with 5-Fu and paclitaxel and examined the subsequent changes of lnc-MBL2-4 : 3 (OTTHUMT00000048112) and lnc-AL355149.1-1 (OTTHUMG00000002490) in response to the drug treatment. This evidence concerns the gene MBL2 and cancer.