To investigate the hypothesis that fetuses with a low EFW and umbilical artery (UA) Doppler abnormalities would exhibit lower concentrations of serum adiponectin and higher levels of leptin, CRP, and proinflammatory cytokines (TNFα and IL-6), we studied these adipocytokines in IUGR mother-child couples in comparison with small for gestational age (SGA) and appropriate for gestational age (AGA). The gene discussed is CRP; the disease is fetal growth restriction.