As shown in Figure 2(d), normal prostate epithelial cells showed low expression levels of both Patch1 and Gli1 (Figure 2(d) panels (B) and (C)), whereas in prostate cancers, in which KCTD11 was either lost or expressed in the cytoplasm, both Patch1 and Gli1 resulted to be overexpressed (Figure 2(d) panels (E)-(F), (H)-(I)). Here, KCTD11 is linked to Familial prostate cancer.