Such miRNAs have been found altered in human tumors; in particular, miR-9 is an oncogenic miRNA overexpressed in mixed lineage leukemia- (MLL-) rearranged acute myeloid leukemia [62], in muscle-invasive bladder cancer [63], and in osteosarcoma cell lines [64]. This evidence concerns the gene KMT2A and acute myeloid leukemia.