For example, canonical histone H3 is incorporated into chromatin by chromatin assembly factor 1 (CAF-1) during DNA replication [42], whereas several histone chaperones, such as HIRA [43], death-domain associated protein (DAXX), α-thalassaemia/mental retardation syndrome X-linked (ATRX), and DEK, are responsible for the delivery of variant histone H3.3 into different genomic loci [44–47]. Here, DAXX is linked to thalassemia.