We have shown previously that LTB4 activates the transient receptor potential vanilloid-1 (TRPV1) ion channel expressed by primary sensory neurons in the ileum resulting in neurogenic inflammation and that inhibition of TRPV1 reduces LTB4- and toxin A-induced ileitis [14, 15]. The gene discussed is TRPV1; the disease is Crohn ileitis.