POMC and hypogonadotropic hypogonadism: Of the nine patients with laboratory evidence of anterior pituitary dysfunction in this series, 8 (88.9%) had panhypopituitarism involving the gonadotrophin, adrenocorticotrophic hormone (ACTH)–cortisol and thyrotrophin axis while one patient had isolated hypogonadotrophic hypogonadism.