CD68 and Hodgkins lymphoma: Further studies are needed to determine the optimal antigen (e.g. CD68 versus CD163), anti-CD68 antibody clone (e.g. KP1 versus PGM1) and scoring thresholds (e.g. manual versus computer-assisted) for detecting HL associated macrophages.49 The Vancouver group developed a 23-gene outcome predictor that was superior to the IPS and to CD68 immunohistochemistry.