TP53 and Hodgkins lymphoma: Several studies indicated that BCL-2 expression in HRS cells is associated with an inferior prognosis.39–41 However, the relationship between BCL-2 expression and patient outcome in HL remains controversial because other studies have not demonstrated the same correlation between bcl-2 expression and failure-free survival.42 Similarly, the association of p53 with patient outcomes in HL remains controversial40–42 although more studies suggest a prognostic role for BCL-2 than for p53.