Increasingly, recent genome-wide analyses of candidate susceptibility genes identified various HLA class II polymorphisms (i.e. DRB5-0101 allele, DRB1*1501-DQA1*0102-DQB1*0602 haplotype and TAP 1 allele) as well as polymorphisms of several cytokine genes (e.g. IL6, IL1R1, IL10, IL4R) which have been linked to risk of HL.33–36 Furthermore, a genome-wide linkage screen performed in 44 high risk HL families showed the strongest linkage finding on chromosome 4p near the marker D4S394.37 Here, IL1R1 is linked to Hodgkins lymphoma.