Increasingly, recent genome-wide analyses of candidate susceptibility genes identified various HLA class II polymorphisms (i.e. DRB5-0101 allele, DRB1*1501-DQA1*0102-DQB1*0602 haplotype and TAP 1 allele) as well as polymorphisms of several cytokine genes (e.g. IL6, IL1R1, IL10, IL4R) which have been linked to risk of HL.33–36 Furthermore, a genome-wide linkage screen performed in 44 high risk HL families showed the strongest linkage finding on chromosome 4p near the marker D4S394.37 This evidence concerns the gene IL4R and Hodgkins lymphoma.