TNF and inflammatory bowel disease: Etanercept, a nonantibody soluble fusion protein composed of the extracellular domain of TNFR2 and the hinge and Fc fragments of human IgG1 antibody [116], is an anti-TNF agent approved by FDA and EMA for treatment of rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis but not IBD.