A large-scale study regarding the use of GDF-15 levels in SA patients published by Schaub et al. [16] showed that when circulating serum GDF-15 levels measurement was added to a clinical risk predictive model regarding CAD mortality, the predictive accuracy improved significantly (from AUC = 0.74 to AUC = 0.85, P = 0.005). This evidence concerns the gene GDF15 and coronary artery disorder.