For example, a patient with breast cancer without hormone receptors (2 points) who had ordinary visceral metastasis (1 point) and elevated CRP (1 point), with poor PS (1 point), and multiple bone metastasis development (1 point) after receiving chemotherapy (1 point) would have a total score of seven points (2 + 1 +1 + 1 + 1 + 1 = 7). This evidence concerns the gene CRP and breast carcinoma.