MMP-9, a gelatinase that degrades type IV and type V collagen and has an established role in cartilage degradation during RA (43), was chosen because of previous reports that MMP-9 release could be induced from the myeloid cell line THP-1 in vitro by either crosslinking of DR-3 (44) or the action of IFNγ and TL1A (26). The gene discussed is SGCG; the disease is rheumatoid arthritis.