SLC22A8 and acute kidney injury: Moreover, Schneider and colleagues reported decreased para-aminohippurate clearance, another protein-bound uraemic toxin, in an animal model of AKI associated with reduced mRNA expression for OAT1 and OAT3 [57], suggesting that OAT1 and OAT3 play a major role in uraemic toxin excretion in AKI.