Guidelines currently suggest (grade 2C) that albumin use should be considered as a resuscitation fluid in patients with severe sepsis, particularly if those patients are not responding to crystalloid infusion [59,60], based on data from the meta-analysis [58] and preliminary data from a multicenter study in France that suggested a nonsignificant reduction in mortality in patients with septic shock who received albumin [61]. This evidence concerns the gene ALB and septic shock.