As the discordance was more important for predicting F ≥ 2, factors possibly associated with these discordances were analyzed, including age; sex; BMI; alcohol consumption; plasma HCV-RNA levels; absolute CD4+ (/mm3) cells; HCV genotype; increased serum AST, ALT, ALP, and GGT (>2N) and bilirubin concentrations; steatosis; cirrhosis; HIV and HCV treatment; and response to HCV treatment. The gene discussed is CD4; the disease is Cirrhosis.