It is of interest that frontal cortical regions have higher CB1 expression than posterior regions (Glass et al. 1997), the neural circuits through the striatum and thalamus to the cortex project mainly to frontal areas (Herrero et al. 2002), and altered CB1 signalling in prefrontal areas may be important in schizophrenia (Dalton et al. 2011). The gene discussed is CNR1; the disease is schizophrenia.