For this programmed cell death by excess lipid deposition in NASH, a lot of reports have expressed c-Jun NH2terminal kinase (JNK) as a potential modulator activating apoptotic effectors such as p-53-up-regulated mediator of apoptosis (PUMA), Bax, Caspase-3 and −9. The gene discussed is MAPK8; the disease is metabolic dysfunction-associated steatohepatitis.