Since ANXA1 has been proved to contribute to the tumorigenesis of various human malignancies, we investigated six of the more frequently occurring tumor entities in human gastrointestinal system (esophagus, stomach, colon, liver, bile duct, and pancreas) for ANXA1 expression to reveal its potential role as a diagnostic marker or as a therapeutic target. Here, ANXA1 is linked to neoplasm.