However, since this study is mainly on the immunostaining level, detailed molecular mechanism studies are needed to address if tubal epithelia with IMP3 signatures actually represent a latent precancer and if it has a synergistic role in facilitating cancer development with TP53. Other studies such as the risk of IMP3 signatures in cancer prediction and overexpression of IMP3 in HGSC in relation to patient survival and response to adjuvant therapies are also pertinent in the near future. This evidence concerns the gene TP53 and cancer.