Polymorphisms in DDX39B (BAT1) have been described in several diseases with inflammatory profiles, including neuropathy, myasthenia gravis, allergies, Alzheimer disease, myocardial infarction, hepatitis, rheumatoid arthritis, Chagas disease, among others [25,43-48]. The gene discussed is DDX39B; the disease is early-onset autosomal dominant Alzheimer disease.