Participants with DDX39B-22/DDX39B-348/TNF-308/IL6-176 genotype combinations GC/CC/GG/GG and GG/CT/GG/GG had decreased and increased risk, respectively, of developing manifestations of malaria relative to asymptomatic participants (OR 0.41, 95% CI 0.17-0.98, P = 0.0428; OR 4.77, 95% CI 1.10-20.59, p = 0.0361; respectively, Figure 3A). This evidence concerns the gene TNF and malaria.