In addition, the genotype combinations GC/CC/GG/GG and GG/CT/GG/GG, corresponding to the respective polymorphisms DDX39B-22/DDX39B-348/TNF-308/IL6-176, were associated with a decreased or increased risk, respectively, of developing mild vivax malaria, probably by altering TNF and IL-6 levels. The gene discussed is TNF; the disease is Plasmodium vivax malaria.