TNF and malaria: Similarly, it is reported here an analysis of susceptibility to clinical manifestations of malaria as a result of genotype combinations found that CG/CC/GG/GG and GG/CT/GG/GG, corresponding to the respective polymorphisms DDX39B-22/DDX39B-348/TNF-308/IL6-176, were associated with decreased and increased risk, respectively, of developing clinical manifestations of P. vivax infection.