Having previously demonstrated NOX2 dysregulation by P2X7 in SOD1-G93A primary microglia (Apolloni et al., 2013a), and given the important role suggested for this superoxide-generating complex in spinal cord microglia during ALS, we further investigated the level of this protein after treatment with BBG. Here, P2RX7 is linked to amyotrophic lateral sclerosis.