To further confirm if miR-2909 targets KLF4 in pediatric B-ALL but not in pediatric T-ALL, we constructed reporter plasmids using the KLF4 3′UTR containing the miR-2909 target site from B-ALL (pGFP-KLF4-3′UTR-B) and T-ALL (pGFP-KLF4-3′UTR-T) patients (Figure 2D). Here, KLF4 is linked to acute lymphoblastic leukemia.