HSPA1A and spinocerebellar ataxia type 1: Manipulation of Hsp70 activity similarly led to contradicting results: In addition to positive clinical effects of Hsp70 overexpression, such as increased resistance to cardiomyopathies [106] and a delay in progression of neurodegeneration in a mouse model of Spinocerebellar ataxia type 1 (SCA1) [107], increased Hsp70 levels could have negative clinical effects, such as promoting cancer cells survival [108,109].