CHIP substrates include clinically-important proteins, among them the glucocorticoid receptor [44], the receptor tyrosine kinase avian erythroblastosis oncogene B-2 (ErbB2) [48], the Alzheimer’s disease related protein tau [49] and the cystic fibrosis transmembrane conductance regulator (CFTR) [50]. This evidence concerns the gene CFTR and glycogen storage disease VI.