It has been reported that the pathogenesis process of rheumatoid arthritis is mainly driven by nuclear transcription factors, such as NF-κB, which is a transcription factor that plays an important role in regulating the expression of many genes involved in immune responses, including the cytokines TNF-α, IL-1β, MMP-1, and MMP-3, all of which are closely involved in the pathogenesis of RA. The gene discussed is TNF; the disease is rheumatoid arthritis.