Of the 3529 patients undergoing HR testing, a total of 2395 (67.9%) cases were hormone receptor positive (ER and/or PR positive; ER+ and/or PR+) breast cancer, with a median age of 48 years (range, 21∼86 years) and a mean age of 48.72 (±10.40) years. The gene discussed is ESR1; the disease is breast carcinoma.