Similarly in the current study at ≤3 hours following cardioembolic stroke, we observed 217 molecules involved in cell death in females, such as CASP1 (caspase1), IRAK3, CREB1, HMGB1, CARD11, NFkB1, BCL2A1, ITGAM (integrin, alpha M), TLR2, INRAF1 (interferon (α, β, γ) receptor 1), STAT5B (signal transducer and activator of transcription 5), CD44, CD59, and MYD88. This evidence concerns the gene HMGB1 and cardioembolic stroke.