ESR1 and neoplasm: The estrogen pathway induces tumor growth in estrogen receptor-positive breast cancers [6]; the PI3K/AKT pathway is an important player in cell survival [9]; the TNF signaling is anti-cancer related pathway [19]; and MEK/ERK pathways are usually associated with proliferation and anti-apoptosis; the NFkB pathway is involved in many cell functions, such as cell proliferation, cell survival, and cellular stress [20]; the JNK/p53/p21 pathway may induce cell apoptosis [8]; and HDAC1/BRCA1/DDB2 is a cell survival pathway [21].