Although the present study did not reveal that the EZH2 g.148505302 T allele has a significant relationship with ESCC risk, Paolicchi and colleagues reported that EZH2 g.148505302 TT genotype was correlated with a significantly longer OS in cholangiocarcinoma (p = 0.026), and moreover, the TT genotype revealed a trend toward a significant association with a reduced risk of mortality [27]. Here, EZH2 is linked to esophageal squamous cell carcinoma.