Thus, in this study, in order to clarify association between EZH2 SNPs rs887569 (g.148505302C > T), rs41277434 (c.2110 + 6A > C) and rs3757441 (c.626 − 394T > C) polymorphisms and ESCC risks, we performed a hospital-based case-control study on Han Chinese population. The gene discussed is EZH2; the disease is esophageal squamous cell carcinoma.