It will also be useful to meliorate MUDPAC by integrating a larger panel of driving alterations beside the mutations, both genetic and epigenetic, such as somatic copy number alteration (SCNA), methylation and transcription factor (TF) etc. Identifying the oncogene and tumor suppressor gene targets of driver SCNAs and elucidate the functional roles of SCNAs have been considered important in cancer diagnostics and therapeutics. Here, TF is linked to cancer.