We applied the method to 29,900 somatic mutations identified in 11,897 genes from 498 breast cancer (BRCA) patients distributed over four subtypes annotated in the Cancer Genome Atlas (TCGA) project [5]: Basal-like (93), HER2+ (57), Luminal-A (224), Luminal-B (124). Here, ERBB2 is linked to breast cancer.