TNF and cystic fibrosis: Moxifloxacin reduced the cytokine-induced activation of the transcription factor NF-κB and MAP kinases and the synthesis of nitric oxide in the alveolar epithelial cell line A549 [17] and the TNF-α-induced NF-κB- and MAP-kinase-dependent expression of inflammatory mediators (IL-6, IL-8) in cystic fibrosis epithelial cells [18].