AKAP8L and Huntington disease: A-kinase anchoring protein 95-like protein, also named HAP95, HA95, or NAKAP95, is a product of gene duplication of A-kinase anchoring protein 95 (AKAP95) [16, 17] and regulates a variety of physical or pathological processes including chromatin condensation, and initiation of DNA replication [16, 18], pre-mRNA splicing [19], pathogenesis of Huntington’s disease (HD) [20], and oncogenesis [21].